Mosaicism in the C-banded region of chromosome 1 in cancer families
Identifieur interne : 000B51 ( Main/Exploration ); précédent : 000B50; suivant : 000B52Mosaicism in the C-banded region of chromosome 1 in cancer families
Auteurs : Luisa Doneda [Italie] ; Annamaria Fuhrman Conti [Italie] ; Valter Gualandri [Italie] ; Lidia Larizza [Italie]Source :
- Cancer Genetics and Cytogenetics [ 0165-4608 ] ; 1987.
English descriptors
- Teeft :
- Adenocarcinoma, Cancer families, Cancer family members, Cancer genet cytogenet, Cancer predisposition, Cancer proneness, Carcinoma, Cell population, Chromosome, Chromosome analysis, Colonic adenocarcinoma, Cytogenet, Different pattern, Family tree, Gastric cancer, Genet, Genetic instability, Healthy subject, Heterochromatic, Heterochromatin, High incidence, Human chromosomes, Lidia larizza, Malignant melanoma, Mosaicism, Possible relationship, Telecobalt therapy, Testicular cancer, Tumor patients, Unequal mitotic, Unstable genotype, Variant.
Abstract
Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.
Url:
DOI: 10.1016/0165-4608(87)90008-2
Affiliations:
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Doneda</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology and Genetics, Medical Faculty, University of Milan</wicri:regionArea><wicri:noRegion>University of Milan</wicri:noRegion></affiliation></author><author><name sortKey="Conti, Annamaria Fuhrman" sort="Conti, Annamaria Fuhrman" uniqKey="Conti A" first="Annamaria Fuhrman" last="Conti">Annamaria Fuhrman Conti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology and Genetics, Medical Faculty, University of Milan</wicri:regionArea><wicri:noRegion>University of Milan</wicri:noRegion></affiliation></author><author><name sortKey="Gualandri, Valter" sort="Gualandri, Valter" uniqKey="Gualandri V" first="Valter" last="Gualandri">Valter Gualandri</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology and Genetics, Medical Faculty, University of 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type="ISSN">0165-4608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-4608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adenocarcinoma</term><term>Cancer families</term><term>Cancer family members</term><term>Cancer genet cytogenet</term><term>Cancer predisposition</term><term>Cancer proneness</term><term>Carcinoma</term><term>Cell population</term><term>Chromosome</term><term>Chromosome analysis</term><term>Colonic adenocarcinoma</term><term>Cytogenet</term><term>Different pattern</term><term>Family tree</term><term>Gastric cancer</term><term>Genet</term><term>Genetic instability</term><term>Healthy subject</term><term>Heterochromatic</term><term>Heterochromatin</term><term>High incidence</term><term>Human chromosomes</term><term>Lidia larizza</term><term>Malignant melanoma</term><term>Mosaicism</term><term>Possible relationship</term><term>Telecobalt therapy</term><term>Testicular cancer</term><term>Tumor patients</term><term>Unequal mitotic</term><term>Unstable genotype</term><term>Variant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Chromosome 1 C-band length mosaicism was detected in lymphocytes from six tumor patients and one healthy subject belonging to three families with a high incidence of cancer. In all cases the variant cell population showed a decreased amount of C-heterochromatin in one chromosome, whereas the C-banded pattern of the homolog was identical to that of the nonvariant cell population. A family tendency to unequal mitotic crossing over, possibly leading to C-band heteromorphism, may explain the high frequency of detection of C-heterochromatin mosaicism in cancer family members (seven of 13 cases studied). The possible role of heterochromatin in inducing cancer has been widely discussed. The special feature of the acquired C-band variants vis-à-vis the inherited ones is that they mark intrinsic genetic instability that may result, through multiple mechanisms, in increased susceptibility to malignancy.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Doneda, Luisa" sort="Doneda, Luisa" uniqKey="Doneda L" first="Luisa" last="Doneda">Luisa Doneda</name></noRegion><name sortKey="Conti, Annamaria Fuhrman" sort="Conti, Annamaria Fuhrman" uniqKey="Conti A" first="Annamaria Fuhrman" last="Conti">Annamaria Fuhrman Conti</name><name sortKey="Gualandri, Valter" sort="Gualandri, Valter" uniqKey="Gualandri V" first="Valter" last="Gualandri">Valter Gualandri</name><name sortKey="Larizza, Lidia" sort="Larizza, Lidia" uniqKey="Larizza L" first="Lidia" last="Larizza">Lidia Larizza</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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